Biological Sciences

The blood-brain barrier deteriorates with aging, but animal studies indicate repairs can make old brains look young again.

In 2014, two years after her Nobel Prize-winning invention of CRISPR-Cas9 genome editing, Jennifer Doudna thought the technology was mature enough to tackle a cure for a devastating hereditary disorder, sickle cell disease, that afflicts millions of people around the world, most of them of African descent. Mobilizing colleagues in the then-new Innovative Genome Institute (IGI) — a joint research collaboration between the University of California, Berkeley, and UC San Francisco — they sought to repair the single mutation that makes red blood cells warp and clog arteries, causing...

Thanks to a rapid funding program thrown together by wealthy entrepreneurs barely six weeks ago, seven COVID-19 research projects at the University of California, Berkeley, are getting an infusion of cash — $2.2 million in all — that could turn up new diagnostics and potential treatments for the infection within months.

Polina Lishko, a Ukrainian-born physiologist whose work at the University of California, Berkeley, has already led to the development of promising new non-hormonal contraceptives for women and could lead to male or unisex contraceptives, has been chosen to receive a 2020 MacArthur “genius” Award.