Biological Sciences

Age vs. genetics: Which is more important for how you age?

October 7, 2022

Amid much speculation and research about how our genetics affect the way we age, a University of California, Berkeley, study now shows that individual differences in our DNA matter less as we get older and become prone to diseases of aging, such as diabetes and cancer.

In a study of the relative effects of genetics, aging and the environment on how some 20,000 human genes are expressed, the researchers found that aging and environment are far more important than genetic variation in affecting the expression profiles of many of our genes as we get older. The level at which genes are...

Like the Borg of Star Trek, these ‘aliens’ assimilate DNA from other microbes

October 20, 2022

Only a meter or two below our feet dwells a wealth of microbes whose riches remain largely unexplored. It’s a realm where bacteria, bacteria-like organisms called archaea and fungi mingle with viruses and other non-living bits of DNA or DNA — all living with, in or on one another.

In that alien world, researchers have now found large DNA molecules that aren’t quite viruses, which are DNA or RNA wrapped in proteins, but that seem to have infected archaea and acquired along the way a slew of genes from their archaeal hosts.

The researchers dubbed these microbes Borgs because,...

Endangered Devils Hole pupfish is one of the most inbred animals known

November 4, 2022

As its name implies, the Devil’s Hole pupfish lives in a truly hellish environment.

Confined to a single deep limestone cave in Nevada’s Mojave Desert, 263 of them live in water that hovers around 93 degrees Fahrenheit year-round, with food resources so scarce that they are always on the edge of starvation, and with oxygen levels so low that most other fish would die immediately. The pupfish, Cyprinodon diabolis, live in the smallest habitat of any known vertebrate.

New research now documents the extreme effect that these harsh and isolated conditions have had on...

Chemistry Nobelist Carolyn Bertozzi’s years at UC Berkeley

October 5, 2022

Carolyn Bertozzi, a professor at Stanford University who today shared the 2022 Nobel Prize in Chemistry, spent her formative and most creative years at UC Berkeley.

After graduating from Harvard University in 1988, she earned her Ph.D. in chemistry from Berkeley in 1993 and, following postdoctoral and faculty positions elsewhere, returned to join the chemistry faculty and Berkeley Lab in 1996.

Says Mike Botchan, Dean of Biological Sciences: "Today's announcement of Carolyn Bertozzi's Nobel prize in Chemistry was in brilliant recognition of a truly creative scientist for work...

Svante Pääbo, former UC Berkeley postdoc, wins 2022 Nobel Prize in Physiology or Medicine

October 3, 2022

The Nobel Assembly at Karolinska Institutet has today decided to award the 2022 Nobel Prize in Physiology or Medicine to Svante Pääbo for his discoveries concerning the genomes of extinct hominins and human evolution. Humanity has always been intrigued by its origins. Where do we come from, and how are we related to those who came before us? What makes us, Homo sapiens, different from other hominins?

UC Berkeley Professor of Integrative Biology Rasmus Nielsen and UC Berkeley Professor...

Un Vistazo al Laboratorio: Celebrating Hispanic & Latinx Scientists

October 2, 2022

Berkeley Letters & Science also spoke to Ixchel González-Ramírez, a PhD candidate in Integrative Biology. González-Ramírez is a plant evolutionary biologist who describes her work as being similar to that of a detective: “My work…pieces together the series of events that had to happen for us to have the diversity of plants that we have today. But unlike a detective, I work on much longer time scales - even before the dinosaurs existed! Since working in evolutionary time is complicated, I use different sources of information (genes, fossils, living plants) and models and statistics that...

Timothy Springer (UC Berkeley B.A. '71) Receives Lasker Award

September 30, 2022

Timothy Springer, the Latham Family Professor of Biological Chemistry and Molecular Pharmacology at Harvard Medical School and Boston Children's Hospital, has been named a recipient of the 2022 Albert Lasker Basic Medical Research Award, one of the world’s most prestigious prizes for biomedical research.

Mega-eruptions linked to most mass extinctions over past 500 million years

September 16, 2022

Mass extinctions litter the history of life on Earth, with about a dozen known in addition to the five largest ones — the last of which, at the end of the Cretaceous Period 66 million years ago, killed off the dinosaurs and 70% of all life on Earth.

A new study, led by scientists at Dartmouth College in New Hampshire, concludes that most of these mass extinctions had one thing in common: They occurred after mega-eruptions that spewed volcanic lava and toxic gases for hundreds of thousands of years, and some for as long as a million years.

The analysis linking mass extinctions...

inclusiveBio Symposium

August 30, 2022

Amidst the last few weeks of summer break, campus is abuzz with preparation for the start of the fall semester. But in all that bustle, staff, faculty, graduate students and postdocs are taking time for the important work of coming together for inclusiveBio (iBio), a day of conversation about diversity, equity and inclusion in the Departments of Integrative Biology and Molecular and Cellular Biology. According to IB graduate student, and long-time organizer, Jessica Aguilar, the symposium took inspiration from an event first hosted by then MCB graduate student...

Her Discovery Changed the World. How Does She Think We Should Use It?

August 16, 2022

It’s entirely possible, maybe even likely, that during some slow day at the lab early in her career, Jennifer Doudna, in a moment of private ambition, daydreamed about making a breakthrough that could change the world. But communicating with the world about the ethical ramifications of such a breakthrough? “Definitely not!” says Doudna, who along with Emmanuelle Charpentier won the Nobel Prize in Chemistry in 2020 for their research on CRISPR gene-editing technology. “I’m still on the learning curve with that.” Since 2012, when Doudna and her colleagues shared the findings of work...