Discover how CRISPR, a technology co-created by a UC Berkeley professor, is being used to transform medicine.
A sickle is a crescent-shaped blade once used to harvest wheat. When red blood cells take on that same curved shape, it signals sickle cell disease –– an inherited condition that causes cells to become stiff and sticky, blocking blood flow and triggering episodes of severe, stabbing pain known as vaso-occlusive crises.
Sickle cell disease affects more than 100,000 people in the United States, with an outsized impact on the Black community, and an estimated 8 million worldwide. It remains a significant cause of childhood mortality globally.
For decades, treatment options were limited to managing symptoms. That began to change with the development of CRISPR, a powerful gene-editing technology that traces its roots to the University of California, Berkeley. In this short video, part of our ongoing video series Born at UC Berkeley, learn about the innovation from our student host, Angela Zhang.
CRISPR, short for “clustered regularly interspaced short palindromic repeats,” allows scientists to precisely alter DNA. The technology was co-created by UC Berkeley professor Jennifer Doudna and French scientist Emmanuelle Charpentier, who were awarded the Nobel Prize in Chemistry in 2020 for the discovery. Doudna holds the Li Ka Shing Chancellor’s Chair in Biomedical and Health Sciences, and is a professor of biochemistry, biophysics and structural biology.