Mouse embryo containing a beta-galactosidase reporter gene replacing the normal noggin gene. Beta galactosidase is revealed by the blue stain and indicates sites of expression of the noggin gene in the brain and in the skeleton. See Brunet, L. J., McMahon, J. A., McMahon, A. P., Harland, R. M. (1998) Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton. Science, 280, 1455-1457.

Mouse development is one area of study in the laboratory of Richard Harland in the Department of Molecular and Cell Biology.