Circularization of R N A by a translation initiation factor and m R N A binding proteins

Double stranded R N A molecules containing a single stranded, capped 5' end and a 3' poly(A) tail were circularized by the poly(A) tail binding protein, the cap binding protein, and a fragment of the adapter protein translation initiation factor eIF4G. The large white particles connecting the two ends of the R N A strand contains these three proteins. This is an example of the work in the laboratory of Alan Sachs in in the Department of Molecular and Cell Biology.

Photo submitted by Alan Sachs